It happened on Kenyon Road in the Town of Williamson around 9:15 Wednesday night.
Wayne County Sheriff's Deputies tell us 20-year-old Zachary Bergen of Williamson was driving Eastbound when he lost control of the vehicle.
The car rolled over several times before coming to a rest in a ditch. He and three passengers were all taken to Strong Hospital.
Two of the victims were flown by Mercy Flight with serious injuries.
Authorities believe speed was a factor in the crash.