The blowout victory easily surpassed Georgia Tech's 49-10 win over Duke on Nov. 14, 2009 as the Yellow Jackets' biggest margin of victory in an Atlantic Coast Conference game.
Georgia Tech (4-3, 3-2 ACC) ended a three-game losing streak by compiling almost 500 total yards.
The Yellow Jackets took advantage of a blocked punt and three Syracuse turnovers for the runaway win.
Linebacker Quayshawn Nealy had an interception and fumble recovery to lead Georgia Tech's defense.
Syracuse, which averaged 342.5 yards rushing in its first two ACC games, was held to 75 yards on 26 carries and 208 total yards. Jerome Smith had 11 carries for 43 yards.
Georgia Tech had 482 total yards, including 394 yards rushing.
Orange starting quarterback Terrel Hunt completed 7 of 14 passes for 68 yards with an interception. Drew Allen took over in the second half and completed 6 of 15 passes for 65 yards with an interception.
Georgia Tech backup quarterback Justin Thomas ran for 95 yards, including a 50-yard scoring run, and Synjyn Days had a 4-yard touchdown run. Laskey had 13 carries for 75 yards and scored on runs of 6, 3 and 1 yards.
Lee threw a 46-yard touchdown pass to Darren Waller early in the second half on his first official attempt of the game. Lee had an incomplete pass wiped out by a Syracuse penalty earlier in the game.